Jean-Louis Paul Selected Research

Cystathionine beta-Synthase (Serine Sulfhydrase)

1/2022	Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse.
10/2018	Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia.
6/2016	Effect of cadmium administration in hyperhomocysteinemic mice due to cystathionine beta synthase deficiency.
2/2015	Molecular rescue of DYRK1A overexpression in cystathionine beta synthase-deficient mouse brain by enriched environment combined with voluntary exercise.
6/2013	Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice.
4/2013	Effect of catechin/epicatechin dietary intake on endothelial dysfunction biomarkers and proinflammatory cytokines in aorta of hyperhomocysteinemic mice.
2/2013	Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice.
9/2011	Protection and reversal of hepatic fibrosis by red wine polyphenols in hyperhomocysteinemic mice.
8/2009	Effects of red wine polyphenolic compounds on paraoxonase-1 and lectin-like oxidized low-density lipoprotein receptor-1 in hyperhomocysteinemic mice.
6/2009	Calpain activation is required for homocysteine-mediated hepatic degradation of inhibitor I kappa B alpha.

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Jean-Louis Paul Research Topics

Disease

22	Hyperhomocysteinemia 01/2022 - 11/2002
10	Homocystinuria 01/2022 - 01/2007
9	Inflammation (Inflammations) 02/2019 - 06/2009
9	Atherosclerosis 10/2017 - 08/2009
6	Insulin Resistance 01/2022 - 10/2008
5	Cardiovascular Diseases (Cardiovascular Disease) 05/2017 - 11/2002
4	Fibrosis (Cirrhosis) 10/2020 - 06/2009
4	Down Syndrome (Down's Syndrome) 02/2020 - 10/2009
4	Cognitive Dysfunction 02/2020 - 02/2013
2	Retinoblastoma (Glioblastoma, Retinal) 02/2013 - 10/2012
2	Obesity 06/2011 - 04/2010
2	Hepatocellular Carcinoma (Hepatoma) 04/2010 - 04/2002
2	Hypertriglyceridemia 05/2008 - 04/2002
1	Body Weight (Weight, Body) 01/2022
1	Hyperaldosteronism (Conn Syndrome) 10/2020
1	Hypertension (High Blood Pressure) 10/2020
1	Hypertrophy 10/2020
1	Essential Hypertension 10/2020
1	Atherosclerotic Plaque (Atheroma) 07/2019
1	Dyslipidemias (Dyslipidemia) 01/2019
1	Non-alcoholic Fatty Liver Disease 01/2019
1	Metabolic Diseases (Metabolic Disease) 01/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2018
1	Neoplasms (Cancer) 01/2017
1	Homocysteinemia 01/2017
1	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2016
1	Colitis 09/2015
1	Disease Progression 09/2015
1	Chronic Kidney Failure (Chronic Renal Failure) 03/2015
1	Glucose Intolerance 09/2014

Drug/Important Bio-Agent (IBA)

17	HomocysteineIBA 01/2022 - 11/2002
14	Cystathionine beta-Synthase (Serine Sulfhydrase)IBA 01/2022 - 01/2007
5	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 02/2020 - 02/2013
5	Methionine (L-Methionine)FDA Link 03/2015 - 01/2009
5	PolyphenolsIBA 03/2014 - 01/2009
5	CholesterolIBA 02/2012 - 04/2002
4	Proteins (Proteins, Gene)FDA Link 02/2019 - 01/2007
4	LipidsIBA 11/2016 - 01/2007
4	Aryldialkylphosphatase (Paraoxonase)IBA 03/2015 - 03/2007
3	CytokinesIBA 01/2019 - 04/2013
3	Phosphotransferases (Kinase)IBA 10/2018 - 10/2009
3	Lipoproteins (Lipoprotein)IBA 01/2017 - 02/2013
3	EnzymesIBA 06/2016 - 01/2007
3	Biomarkers (Surrogate Marker)IBA 04/2013 - 08/2009
3	Catechin (Z 7300)IBA 04/2013 - 03/2007
2	LDL Lipoproteins (beta Lipoproteins)IBA 07/2019 - 01/2014
2	Insulin (Novolin)FDA Link 01/2019 - 10/2008
2	quinone (benzoquinone)IBA 05/2017 - 10/2009
2	NAD (NADH)IBA 05/2017 - 10/2009
2	AdenosylhomocysteinaseIBA 05/2017 - 10/2009
2	Drinking WaterIBA 06/2016 - 08/2009
2	XenobioticsIBA 06/2016 - 08/2011
2	Phosphatidylcholine-Sterol O-Acyltransferase (Lecithin Cholesterol Acyltransferase)IBA 03/2015 - 11/2013
2	Apolipoprotein A-I (Apolipoprotein A1)IBA 03/2015 - 11/2013
2	ResistinIBA 09/2014 - 03/2014
2	AntioxidantsIBA 03/2014 - 04/2013
2	ResveratrolIBA 03/2014 - 01/2009
2	HDL LipoproteinsIBA 11/2013 - 04/2002
2	Biological ProductsIBA 02/2013 - 08/2009
2	Scavenger Receptors (Scavenger Receptor)IBA 04/2010 - 01/2007
2	FlavonoidsIBA 08/2009 - 03/2007
2	CalpainIBA 06/2009 - 01/2009
2	Sulfhydryl Compounds (Thiols)IBA 01/2009 - 11/2002
2	Fatty Acids (Saturated Fatty Acids)IBA 10/2008 - 01/2007
1	CystathionineIBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	SaltsIBA 10/2020
1	AldosteroneIBA 10/2020
1	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 02/2020
1	LipopolysaccharidesIBA 02/2019
1	calpastatinIBA 02/2019
1	CeramidesIBA 01/2019
1	Small Interfering RNA (siRNA)IBA 01/2018
1	InflammasomesIBA 01/2018
1	Sirolimus (Rapamycin)FDA Link 10/2017
1	Mycophenolic Acid (Cellcept)FDA LinkGeneric 10/2017
1	Gemcitabine FDA Link 01/2017
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2017
1	SqualeneIBA 01/2017
1	Pharmaceutical PreparationsIBA 01/2017
1	CadmiumIBA 06/2016
1	Heavy MetalsIBA 06/2016
1	Rosuvastatin Calcium (Crestor)FDA Link 04/2016
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 04/2016
1	Interleukin-10 (Interleukin 10)IBA 09/2015
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 09/2015
1	VitaminsIBA 03/2015
1	Alanine Transaminase (SGPT)IBA 03/2015
1	Triglycerides (Triacylglycerol)IBA 09/2014
1	Superoxides (Superoxide)IBA 03/2014
1	Kruppel-Like Factor 4IBA 01/2014
1	oxidized low density lipoproteinIBA 01/2014
1	MicroRNAs (MicroRNA)IBA 01/2014
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2014
1	Kruppel-Like Transcription Factors (Kruppel-Like Factors)IBA 01/2014
1	Fenofibrate (CiL)FDA LinkGeneric 06/2013

Therapy/Procedure

1	Organ Transplantation 10/2017
1	Art Therapy 04/2016
1	Therapeutics 03/2015
1	High-Protein Diet 03/2014